There are so many items to choose from in 168澳洲幸运5开奖网:The Binding of Isaac: Repentance. It can be hard to know whether the wacky components that make up your loadout will hinder you or make your run a success. Sometimes, surprisingly, the items that appear to be rather weak and tend to be forgotten will help you the most. The community may favor c🦩ertain iconi꧟c and powerful items, but every Isaac run is different, and you never know which ℱstrange powers will boost you to victory.

Related: 168澳洲🍸幸运5开奖网:Game-Breaking Synergies In The Binding Of Isaac

Although certain items may seem like they won't synergize at all, sometimes they can create amazing results. These unique and underrated power-ups might even have you getting those completion marks that you've been needing to tick off for ages.

10 ജ♋ Rotten Tomato

The Rotten Tomato item- A rotten tomato - it looks dead, and has a fly around its head. From The Binding of Isaac: Repentance

The Rotten Tomato has a chance to mark and slow your enemies. If you have been lumbered with Luck-reducing pills, this item may not work in your favor. On the other hand, if you are playing a character like Cain or have an item such as Lucky Foot you will be in💝 a better position, and the Rotten Tomato can synergi꧃ze with other items.

Although the Rotten Tomato is a luck-based item, it's truly underrated. If you're in a room full of enemies, and a single one gets marked, they're all going to gang up on each other and fight to the death. This gives you a second to catch your breath at the very least, a potentially very powerful effect.

9 It Hurts

A bloodied sewing needle. The It Hurts item, from The Binding of Isaac: Repentance

With It Hurts, taking damage causes Isaac to release a circle o🦄f ten tears which do ten damage. After taking damage, he will then gain a +1.2 Tears Up for the rest of the room. Any additional hits give him a +0.4 Tears Up, ignoring the cap. If you are playing as Maggie or are otherwise in a position to tank damage, this can be very useful; a great room clearer that can get you out of sticky situations.

This item boasts particularly great synergy with Tainted Maggie (168澳洲幸运5开奖网:one of the many Tainted characters), It's also a very gruesome item. It Hurts is underrated for the sheer amount of damage it can output if you're surrounded by enemies; a real lifesaver.

8 Stitches

Stitches, a doll from The Binding of Isaac: Repentance

Stitches is a fantastic bait and switch tool. It spawns an item that can be moved around and deals 1.5 tick damage to any enemy it touches. When activated, you teleport and swap places with Stitches, spawning in th💧e place the familiar previously occupied. It can be incredibly handy for extinguishing fires, bamboozling enemies, and getting you into Curse Rooms for free.

Related: Th൩e Binding Of Isaac Rebirth: How To Unlock All Endings

It can be a difficult item to use, which is why not many people choose it, but it is worth the ris﷽k. It takes a lot of practice to master this technical tool, but it can be a game-breaking item.

7 ✱ Vඣanishing Twin

Vanishing Twin, with flavor text beneath that reads 'He Wants Revenge'. The Binding of Isaac: Repentance

Vanishing Twin is a very risky yet powඣerful item. It turns into a familiar that follows Isaac around and, once inside a boss room, copies the boss and becomes them. This means you have to fight both of them at the same time. However, you will be given two boss drops at the end of the encounter. If you have enough damage, health and skill to withstand the fights, this is absolutely worth doing.

Vanishing Twin can synergize well with Tainted Isaac, who will have the choice between four boss items in total due to his cycling ability. This is an underrated item because most players are daunted by it, but if you're brave enough to use it, the rewards are wonderful.

6 TMTrainer

A glitched out item called TMTrainer, from The Binding of Isaac: Repentance

TMTrainer is a wild item that was added to the Repentance expansion. It can completely break your run, as you have no idea what it will turn your items into. For that reason, everyone should take 𓃲it, just for fun. It has the potential to unlock achievements or take you to places that you wouldn’t usually be able to get to without it.

It may give you some excellent items, it may not, but the experience is there to be had. What a beautiful item. It's just so ridiculous. None of the effects make any sense, and it will have you in fits of laughter. All fans should just give it a go just to see where they end up with this item.

5 Eye Sores

Isaac standing in front of the item Eye Sores, The Binding of Isaac: Repentance

Eye Sores sounds like it’d be a pretty weak item, but it can hit enemies that are in your peripheral vision while you may be getting overcrowded by other mobs. This can be a really helpful item. It also synergizes very nicely with Brimstone or Technology if you have those power-ups, so 168澳洲幸运5开奖网:Azazel and Tainted Azazel players in particular would be advised to try Eye Sores for 🌠themselves when they get the chance.

It's a blast to spew tears in every direction with this item, though it's one that a lot of players would be loath to use. It's far more effective than it may appear.

4 False PhD

A poorly written PHD, labelled False PHD. The Binding of Isaac: Repentance

False Ph.D. essentially flips the effects of pills. Any stat-reducing pill gives ✅you a damage boost, for instance, and any other pills (such as R U A Wizard? Amnesia, and The Bad Trip) will spawn a Black Heart.

Related: The🉐 Binding Of Isaac: Ranking All Of The Planetarium Items

In addition, this item spawns a Black Heart when picked up, which can be useful. Although it's a bit scary to take this item, it's worth it to do so on a character who's on the tankier side. If you have a lot of health, you may be in better standing to deal with the side effects of the pills collected. It'll be worth it in the long run, because you'll be getting damage stat increases and Black Hearts. This item is underrated for similar reasons as the Vanishing Twin: Players are afraid of bad results, but this item can be incredibly useful in the long run. Take a risk and find out what happens!

3 Cube Baby

A zoomed in image of the Cube Baby item, The Binding of Isaac: Repentance

Cube Baby is very useful if you are good at aiming your kicks. It can slow down the ﷽enemies and even freeze them, potential causing a chain reaction of frozen foes. It is a very beneficial item. It can be a distracting one too, though, as you can easily end up spending time just kicking Cube Baby around like a football.

Be mindful of your surroundings when using it, then, lest you end up walking into spikes. This pick-up is underrated because it's essentially a lesser version of Freezer Baby, but some people may prefer the extra activity of interaction Cube Baby offers. It has a lot of potential.

2 Urn Of So♓uls ও

A ceramic urn, with a subtitle "Unleash their sorrow" The Binding of Isaac: Repentance

Urn of Souls is a very powerful but tricky item (168澳洲幸运5开奖网:the Repe🐓ntance update added some fanta🌺stic ones); one of the best to use if employed correctly. It collects souls within it as Isaac defeats enemies, and can be used as a portable flamethrower. You have to be careful with how much you use it, though, as it’s very easy to run out of souls if you can't defeat a steady stream of enemies quickly enough.

Isaac is also pushed back ever so slightly when a🌸ctivating it, so keep that in mind as well. Some more popular items are more user-friendly and reliable in terms of their damage, but with practice, the Urn♒ of Souls will prove incredibly powerful too.

1 Voodoo Head ♓ ꦉ

Isaac picking up Voodoo Head in the shop, The Binding of Isaac: Repentance

Voodoo Head creates an extra Curse Room. If you have Dark Arts or are playing as Tainted Judas (or otherwise have the ability to get in there for free), this is very useful, as there is the possibility of getting extra items or other valuable resources. 168澳洲幸运5开奖网:You may even find powerful trinkets.

Sometimes, of course, you're met with some very unfriendly things in Curse Rooms, so keep that in mind. Curse Rooms have suffered a nerf and perhaps aren't the powerhouses they once were, so it makes sense that the Voodoo Head item isn't particularly popular. Even so, the wacky effects that result can make a run (or potentially break it) if you're feeling bold.

NEXT: The Binding Of I🏅saac: Ever🌳ything You Need To Know About Repentance