From the creative mind of Edmund McMillen came a dungeon crawler inspired by The Legend of Zelda, loaded with religious, astrological, pop culture, and toilet humor references. 168澳洲幸运5开奖网:The Binding of Isaac was released in 2011 and has undergone a complete rﷺe-release since, along with four expansions. The latest of them, Repentance, was released at the end of March of 2021 and has received many updates.

RELATED: Things You Didn't Know About The Binding Of Isaac

Each playthrough is a new experience, with every room and floor being randomly generated. The list of achievements, collectibles, and enemies is ever-growing. If you are lucky enough to unlock or stumble across certain items, though, yo🌱ur run is likely to go far bett🌟er. Some items can only be unlocked by finishing the 20+ endings in the game, but some of the best can be found during a first playthrough of the game.

Updated September 2022 by Doruk Kaptan: The Binding of Isaac is quite possibly the most influential roguelike of the past decade. With an incredible amount of content being added to the game and great community interaction by the creators of the ga✱me, it has become the favorite of many indie-game fans over the years.

Several changes were made, and tons of new content has been added through expansions, DLCs, and 168澳洲幸运5开奖网:even mods. Thus, The Binding of Isaac has become a huge game with practically infinite replayability. With over 700 items currently, some are bound to outshine others in terms of strength.

25 Glowing Hour Glass: It's Rewind Time

The Binding of Isaac: Repentance screenshot of Isaac standing in front of Glowing Hour Glass

Glowing Hour Glass offers you one of the most powerful abilities in The Binding of Isaac: a chance to fix your mistakes. Say you lose too many hearts during a boss fight and miss the Devil or Angel Room. Or say you take a ꧟mystery item, and it turns out to ruin your game. With only a three-room charge, this active item can undo any of those actions by rew𒆙inding time and returning you to the last room you were in.

Suppose you don't like an item in a Treasure Room. In that case, you can also use Glowing Hour Glass to prevent yourself from opening the door in the first place, increasing your chance of finding powerful 168澳洲幸运5开奖网:astrological items in Planetariums.

24 Mutant Spider: Quadrupl🎃e Your Tears

The Binding Of Isaac obtaining Mutant Spider in a treasure room

It's always useful to cover ample ground with your tears in the chaotic dungeons that make up this game, and the Mutant Spider is a great way to do so. While it's nothing too spectacular visually, being able to spray four shots in a sweeping arc can be very efficient in st𒊎aving off pursuing foes.

This item is great on its own, but it comes with a decrease in your tear rate that's nothing to scoff at. If you can combine it with at least one item that increases your tear rate again, Mutant Spider can be a run-saving item. More tears are always fun, so that also makes this item desirable.

23 ꧃ Anima Sola: Shackle Yourꦇ Enemies

The Binding of Isaac: Repentance screenshot of Anima Sola chains holding Monstro

From the fiery pits of hell emerge the red-hot chains known as Anima Sola. You'll get a lot of experience using this item 168澳洲幸运5开奖网:as Tainted Jacob since it's his "pocket" active item, but it only meets its full potential when you start using it with other characters. Activating it will shackle the enemy closest to you, preventing them from moving and attacking for five seconds. This still leaves the enemy vulnerable to your tears, so you can get in a few safe hits before they're unfrozen.

Anima Sola can even prevent bosses like Hush from firing their tears or Delirium from transforming and teleportin🐼g. But the best featu😼re is how it recharges: instead of having to clear rooms to use the item again, it recharges every 15 seconds. These two factors make it an invaluable item to use against end-game bosses.

22 ♍ܫ 4.5 Volt: Damaging Enemies Recharges Active Items

The Binding of Isaac: Repentance screenshot of Isaac picking up 4.5 Volt

Th🔯is is perhaps one of the most situational items in the game, but finding a good use for it lets you break everything. Found quite commonly in the Shop, this battery item prevents 💦your active items from charging normally and instead makes you gain charges by hurting enemies. This item heavily relies on your active item since not every item will benefit from charging through damage.

RELATED: Best Character Mods🐎 For The Binding Of Isaac:ཧ Repentance

Because the damage dealt by active items like Mega Blast, Crack the Sky, and Shoop Da Whoop will recharge the item in question, you'll be able to use it many consecutive times against bosses. This alone is enough to make 4.5 Volt worth it, but with either the Doorstop trinket, the Mercurius item, or a golden bomb, you can walk in and out of the same room to gain infinite charges on almost any item.

21 Tech X: Turn 🉐Your Tears Into A Laser Ring

The Binding Of Isaac shooting Tech X tear at three mushrooms

Tech X is an upgrade over previous technology items — the familiar single-direction laser is turned into a slow-moving ring with a near-infinite range. The longer you charge the ring, the larger it becomes and the more damage it does. But be warned: only the outer section of the ring deals damage, and it passes through enemies and obstacles, so you'll have to adapt to a new firing method.

Tech X is also a great item to pair with status effects like fire and poison since the laser ring can inflict damage on enemies more than once as it passes through them. With no drawbacks, this 🦩is for sure a great tear replacement.

20 🅠 ꦫ Holy Mantle: Negate Damage Once Per Room

The Binding Of Isaac obtaining Holy Mantle in a treasure room

There aren't many bells and whistles to this minimalist item, but it's suitable for helping Isaac survive. This blessed shield protects Isaac from taking damage by deflecting one hit from almost any source, including those pesky Spiked and 168澳洲幸运5开奖网:Mimic Chests. This may not sound like much, but what's really handy is that the shield will be restored each time another room is entered.

This not only gives it longevity as a life-saver, but it also allows Isaac to enter Curse Rooms without getting hurt. Holy Mantle caꦛn also be used offensively when paired with the right items, such as Midas Touch, which will instantly turn foes into gold following the nullified first hit.

19 D Infinity: All The Dice At Once ✃

The Binding of Isaac: Repentance screenshot of Isaac walking towards D Infinity

As a rule, any item that gives you more choices is incredible in The Binding of Isaac, and the D Infinity is the epitome of that rule. Only found in the Secret Room, this active item lets you access all the♛ dice in the game for a range of different reroll effec🐈ts. You can reroll items with the D6, pickups with the D20, your stats with the D8, or your entire run with the D4.

Related: The Binding Of𒁏 I𓆉saac: Every Dice Room And What They Do

Swapping between the different effects is as simple as pressing the button to swap cards, but you'll only be able to tell what die you're swapping to if you know how all the dice items look. Don't let that stop you from picking up and experimenting with the D Infinity because it has insane potential once you know how to use it.

18 ꧂ ♛ Mega Blast: Huge Laser Beam, Huge Damage

The Binding of Isaac: Repentance screenshot of Mega Blast beam traveling across a Sacrifice Room

Mega Blast is the mother of all damaging active items. You want damage? This one dishes it out like it's nobody's business, assaulting enemies with a gigantic laser beam that nearly covers the screen. You want even more damage? You can carry on firing the beam for 15 seconds while you walk through different rooms.

Mega Blast's main drawback is that it has a 12-room charge, but if you time it well enough, you can recharge it almost halfway before the beam goes away. If you've ever wanted to become a final boss, this item is your best chance.

17 The M൲ind: Knowledg🔴e Is Power

The Binding of Isaac: Repentance screenshot of Isaac standing in front of The Mind

Similar to 168澳洲幸运5开奖网:other excellent roguelikes, The Binding of Isaac has Secret Rooms packed with goodies on every level. Exploding certain walls can reveal these rooms, but because bombs are a limited resource, you won't always be able to find what you're looking for. However, with The Mind, things become much easier. This Angel or Treasure Room item has the combined effect of all the mapping items in The Binding of Isaac, revealing the location of all rooms on the floor.

By knowing exactly where everything is, you'll have the power to avoid dangerous rooms, make a beeline for items or the boss at any time, and bomb open every Secret Room with 100 percent accuracy. Traveling faster through the floors will also help you get to Boss Rush or Hush before they become inaccessible, so The Mind provides no shortage of benefits.

16 🔥 Revelation: Holy Beam Of Death

The Binding Of Isaac shooting a light beam at enemies with the Revelation item

An awesome new addition to the Repentance DLC, this item impresses with an array of perks. These include the ability to take flight, two soul hearts, and most critically, a powerful beam that blasts all in its path. The holy beam needs to be charged and can only be unleashed by releasing the fire buttons, but it doesn't replace your tears or reduce their fire rate.

Since enemies in its path are inflicted with damage equal to Isaac's damage stat, Revelation is a powerful offensive tool. This already potent beam can be further augmented with items like Spoon Bender, which adds a nifty homing feature to the laser.